https://www.selleckchem.com/pr....oducts/ono-7300243.h
BACKGROUND AIMS Shiga toxin (Stx)-producing Escherichia coli (eg, O157H7) infection produces bloody diarrhea, while Stx inhibits protein synthesis and causes the life-threatening systemic complication of hemolytic uremic syndrome. The murine intestinal tract is resistant to O157H7 and Stx, and human cells in culture fail to model the complex tissue responses to intestinal injury. We used genetically identical, human stem cell-derived intestinal tissues of varying complexity to study Stx toxicity in vitro and in vivo. METHODS I
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