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The CD138int FO B cells showed an anergic gene phrase profile shared with compared to monoclonal anergic B cells expressing engineered BCRs plus the gene phrase profile had been different from those of plasma cells, age-associated B cells, or germinal center B cells. The anergic state associated with CD138int FO B cells was verified by attenuated Ca2+ response and failure to upregulate CD69 upon BCR wedding with anti-IgM, anti-IgD, anti-Igκ, or anti-IgG. The BCR repertoire associa