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The main factors that influence the microalgal cultivation and fermentation process, as well as the processes of transformation of biomass into the easily fermentable substrate are also discussed.Rhodopsin (RH1), the temperature-sensitive visual pigment, attained cold adaptation by functional trade-offs between protein stability and activity. Recent studies suggested convergent selection pressures drove cold adaptation of rhodopsin in high altitude catfishes through nonparallel molecular mechanisms. Here, we tested whether the similar s