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Persistent liver inflammatory damage is the main risk factor for developing liver fibrosis, cirrhosis, and even hepatocellular carcinoma in chronic hepatitis B (CH patients. Thus, accurate prediction of the degree of liver inflammation is a high priority and a growing medical need. To build an effective and robust non-invasive model for predicting hepatitis B-related hepatic inflammation. A total of 650 treatment-naïve CHB (402 HBeAg-positive and 248 HBeAg-negative) patients who underwent liver biopsy were enrolled in this study. Hist