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How Does ADHD Medication Work? When one neuron sends an information to another, it uses chemicals called neurotransmitters. These chemicals must pass through a tiny gap known as a synapse. Some ADHD medications help in the transmission of these messages more effective. They can help neurons release more neurotransmitters or slow the reuptake process (called reuptake inhibitors). Doctors place patients with ADHD with a small dose of medication and t