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Consequently, there clearly was a growing importance of building new experimental approaches capable of exploiting the information obtained through the high-resolution snapshots to be able to explore the powerful top features of membrane proteins. Right here, we present the basic concepts of hydrogen-deuterium change mass-spectrometry (HDX-MS) and recent advancements with its used to study membrane layer transporters. In HDX-MS experiments, small amounts of a protein test can help investigate its structural
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