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However, several fundamental challenges, such as intracellular delivery, solubility, physiological stability, and clearance, still need to be addressed before PNAs become broadly applicable in clinical settings. In this review, we summarize the recent advances in PNAs as antibacterial agents and the challenges that need to be overcome in the future.Background Triterpenes is a large group of secondary metabolites mainly produced by plans with a variety of biological activities including potential antitumor effects. Hepatocellular carcino