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These results highlight the potential of oridonin as a therapeutic agent for liver fibrosis. © 2020 The Authors. Drug Development Research published by Wiley Periodicals, Inc.This article recommends the development of broad policies of preclusion regarding the use of incarceration for offenders who are highly unlikely to commit a violent crime in the future. The proposal builds on the new Model Penal Code Sentencing's provision on the limited utilitarian purposes of incarceration. Such low-violence-risk-preclusion strategies (LVRPs) would stand on the most