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ADHD OTC Medication Most children and adults who use ADHD medication will experience a few adverse side effects. These include changes in heartbeat as well as a loss of appetite. upset stomachs. A healthy diet and sufficient sleep can minimize these side effects. Stimulant drugs boost communication between brain cells, which helps children focus and manage impulses. They can also trigger an increase in blood pressure or tics. These drugs are controlled substances that can be crushed or snorted to crea