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How Does ADHD Medication Work? When sends a message to another neuron, it uses chemicals called neurotransmitters. They must cross a tiny gap called a synapse. Some ADHD medications can make the passing along of these messages more effective. They may aid neurons in releasing more neurotransmitters or slow the process of reuptake (called Reuptake inhibitors). Doctors begin ADHD patients with a low dose and then monitor their response. They gradually increase the dosage to discover th