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How Does ADHD Medication Work? When one neuron sends a message to another, it makes use of neurotransmitters, chemicals. These chemicals must cross the gap, which is known as a synapse. Certain ADHD medications increase the efficiency of these messages. They either aid neurons in releasing more neurotransmitters or slow down the process of reuptake (called Reuptake inhibitors). Doctors start ADHD patients on a low dosage and monitor their reaction. They gradually increase the dosage