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MicroRNAs affect the cancerous biological behaviors such as tumor proliferation and metastasis by regulating their particular target genetics. In this study, we investigated the part and apparatus of miR-384 in osteosarcoma. Quantitative real-time polymerase sequence effect assay had been done to identify the expression of miR-384 and insulin-like growth factor binding protein 3 in osteosarcoma tissues and cell lines and founded its correlation with osteosarcoma cyst development a