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How Does Medication For ADHD Work? Most people find that their symptoms improve when they take medication. Finding the right medication at the right dose requires time, open communication and patience with your GP. Medicines that treat ADHD are able to alter the levels of certain chemical messengers in your brain. Stimulant medicines, like methylphenidate, aid in concentration and reduce impulsivity and hyperactivity. Atomoxetine (Strattera) and Guanfacin