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afety beyond mandatory CVOTs. Two issues on clinical trials with multiple endpoints were surveyed (1) the terminology of multiple endpoints, relationship between rare events and endpoints, and differences in multiplicity adjustment between regions; and (2) the current practice on multiplicity adjustment and sample size calculation. This article provides a summary of the results of a survey on the first issue. The survey was conducted among 63 members of the Japan Pharmaceutical Manufacturers Association from October to November 2017. Th