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Phosphatases tend to be regarded as the black sheep, the strangers, of phosphorylation-mediated signal transduction, specially when it comes to medication development and development. This is certainly because of previous difficulties to review all of them and unsuccessful attempts to target all of them; but, phosphatases have regained strong interest and are earnestly pursued today in medical tests. By giving instances for present hot topics in phosphatase biology and for brand-new methods to target them, its il