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Discussion There are a number of assumptions underlying these estimates, but overall all of them seem to be conservative. Copyright © 2020 Rehm and Shield.Malignant mesothelioma (MM), especially its more frequent form, malignant pleural mesothelioma (MPM), is a devastating thoracic cancer with limited therapeutic options. Recently, clinical trials that used immunotherapy strategies have yielded promising results, but the benefits are restricted to a limited number of patients. To develop new therapeutic strategies and define predictors