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First Line Treatment For ADHD in Adults Some people with ADHD find that medications help to manage their symptoms. Drugs like methylphenidate and amphetamine help by enhancing brain activity in the areas that regulate attention and behavior. Other medications, such as the non-stimulant atomoxetine, and other antidepressants, work differently but are equally effective. Regular visits to the GP is recommended for patients who take medication. They can alter dosages and monitor the body's reactions. Medication Adult