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23 ± 176.53 ng/ml; TNF-α 57.53 ± 3.87 pg/ml), while markedly been suppressed in the treatment group (AS-L IgE 1100.25 ± 135.32 ng/ml; TNF-α 38.47 ± 3.26 pg/ml; AS-H IgE 459.46 ± 74.75 ng/ml; TNF-α 24.38 ± 3.85 pg/ml). Among Th17 cell-related factors, DNCB treatment increased mRNA expression of IL-6, IL-17, IL-23, STAT3, and ROR-γt, but reduced TGF-β and SOCS 3; While artesunate reverse these changes. Compared with the model group, artesunate promoted SOCS3 protein and significantly inhibited ROR-γt protein and STAT3 phosphorylation. Thus,