https://www.selleckchem.com/products/kpt-185.html
To confirm a role for nuclear BK channels, these experiments were repeated in isolated nuclei and similar results were found. Ca and calmodulin-dependent kinases (CaMK) have been demonstrated to regulate CREB phosphorylation. Inhibition of CaMKII and CaMKIV resulted in the reversal of paxilline-induced CREB phosphorylation. These results suggest that nuclear BK channels regulate CREB phosphorylation in macrophages. Nuclear located ion channels may therefore be part of novel signalling pathways in macrophages and should be taken into acc
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