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Worldwide, colon cancer is the third most common male malignancy and the second most common female malignancy, following lung cancer. Since 2011, the Republic of Kazakhstan has consistently implemented national health reform programs, for which improving the quality of cancer care is one of the main priorities. This study aimed at evaluation of colon's cancer morbidity and mortality within the period of 14 years (from 2004 to 2017). We observed an increase in the morbidity of colon cancer among the population of Kazakhstan, which may be