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Early remission was observed in 47 (65%) patients 6 months after surgery. MGMT expression was 75% in half of all tumours, 25% in 14 tumours, and 25-50% or 50-75% in 11 tumours. Lower MGMT expression was associated with alarger tumour diameter (p = 0.001), higher adrenocorticotropic hormone (ACTH) concentration (p = 0.002), higher p53 expression (p = 0.026), and higher frequency of sparsely granulated corticotroph adenomas (p = 0.009). Low MGMT expression was significantly related to lower frequency of early clinical remission (
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