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The dose-response analysis uncovered that even a small amount of industry payments had been enough to efficiently impact doctors' prescription practice of opioids. CONCLUSIONS Opioid-related industry payments to doctors within the prior year had been related to an increased wide range of opioid prescriptions and expenses for opioid products into the subsequent 12 months. © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Posted by BMJ.BAC