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Extending these in vitro and ex vivo observations, some prebiotics have been well investigated, with successful human and animal trials demonstrating the association between gut microbes and immunity biomarkers leading to improvement in health endpoints across populations. This review discusses scientific insights into the association between prebiotics, innate immunity and gut microbiome from in vitro to human oral intervention.The reaction of [Cp'''Ni(η3 -P3 )] (1) with in situ generated phosphenium ions [RR'P]+ yields the unpreceden