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Overall, 66% of smokers were prescribed pharmacotherapy. Over one in five of all smokers admitted during this pilot reported that they were abstinent from smoking 12 weeks after discharge (22%) at a cost £183 per quit. DISCUSSION National implementation of this cost-effective programme would be likely to generate substantial benefits to public health. © Royal College of Physicians 2020. All rights reserved.Late HIV diagnosis is associated with significant mortality in people living with HIV (PLWH) and high numbers of missed opportunities