https://www.selleckchem.com/pr....oducts/VX-680(MK-045
In contrast, the intracellular fluid pressures were relatively uniform with reserve zone tissue depth and less sensitive to epiphyseal permeability. Fluid shear stress, induced by fluid flow over the cell surface, provided mechanoregulatory signals potentially sufficient to stimulate reserve zone chondrocytes near the subchondral bone plate interface. These results suggest that the strain rate and tissue depth dependence of cell-level strains and cell surface fluid shear stress may provide mechanoregulatory cues in the reserve z
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