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Racial differences in genetic risk factors for venous thromboembolism (VTE) are elucidated, with factor V Leiden and prothrombin G20210A being prevalent among the Caucasian population but rare among non-Caucasians. To assess the worldwide distribution of three gene polymorphisms previously identified as genetic risk factors among East Asian subpopulations protein S (PS) Tokushima (p.Lys196Glu), protein C (PC) p.Arg189Trp, and PC p.Lys193del. An international collaborative study group of seven centers in five countries-Japan, South Korea