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We characterized two diverse cuproptosis-associated molecular isoforms in CRC which display distinct prognostic and TME qualities. Afterwards, we built a cuproptosis-associated prognostic model containing five genes and divided the patients into increased CPS-score team and a low CPS-score group. Univariate and multivariate Cox analyses showed that the CPS rating could be made use of as an independent prognostic factor. The nomogram, and its consequent calibration curves, indi