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To evaluate the preload dependence of femoral maximal change in pressure over time (dP/dtmax) during volume expansion in preload dependent and independent critically ill patients. Retrospective database analysis. Two adult polyvalent ICUs. Twenty-five critically ill patients with acute circulatory failure. Thirty-five fluid infusions of 500 mL normal saline. Changes in femoral dP/dtmax, systolic, diastolic, and pulse femoral arterial pressure were obtained from the pressure waveform analysis using the PiCCO2 system (Pulsion Medic