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Nail melatonin levels immediately rose after management and moved right back to pre-administration values after ≈100 days both in volunteers. Our results declare that melatonin determination in fingernails is an appropriate non-invasive device for the estimation of global melatonin production. Because of the simple collection and storage space of nails, the long-lasting information acquired while the several features of melatonin, nail melatonin content might complement dim light melatonin beginning,