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OBJECTIVES To assess the association of cholecystectomy with the risk of prostate cancer in patients with gallstones. METHODS This nationwide population-based cohort study was conducted by retrieving the Longitudinal Health Insurance Research Database (LHID200 for inpatient claims in the Taiwan National Health Insurance (NHI) program. The study cohort consisted of 72,606 men aged 20 years with gallstones undergoing cholecystectomy between 2000 and 2010. The control cohort consisted of the men with gallstones, but without cholecystect