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s in b value, but no significant differences were observed between all renal tumors and the normal renal cortex. A linear correlation was found between α values and NIC in CP (r=0.780, P=0.0 and NP (r=0.693, P=0.0. The b values and NIC had a low correlation in CP, with no correlation in NP. Quantitative spectral CT with the stretched-exponential nonlinear regression analysis model may enhance the differential diagnosis ability for renal tumors. Its clinical value remains to be further explored in other types of soft tissue lesions. Quantitative spectral