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To study whether the consumption of ultra-processed foods and drinks is associated with breast, colorectal, and prostate cancers. Multicentric population-based case-control study (MCC-Spain) conducted in 12 Spanish provinces. Participants were men and women between 20 and 85 years of age with diagnoses of colorectal (n=1852), breast (n=1486), or prostate cancer (n=953), and population-based controls (n=3543) frequency-matched by age, sex, and region. Dietary intake was collected using a validated food frequency questionnaire. Foods and