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The results of this study outline the relationship between the micromechanical and structural behaviour of cortical bone during plastic deformation, providing information on cortical tissue fracture pathways.Adverse reaction to metal debris (ARMD) is an issue in metal-on-metal (MoM) total hip replacements (THR). It mainly affects large-head MoM THR, whereas 28-32 mm MoM pairings are associated with low long-term revision rates. However, the bearing surface is not necessarily the only cause of metal debris. This report documents with adva