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Although OUD and using tobacco tend to be very comorbid, most prior neuroimaging analysis in OUD failed to manage for smoking severity. Particularly, the combined effect of smoking cigarettes and OUD in the mind grey matter volume (GMV) continues to be unknown.Objectives We utilized architectural magnetic resonance imaging (sMRI) to analyze (1) the GMV differences when considering OUD and non-OUD individuals with similar smoking cigarettes seriousness; and (2) the dif