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The model is then able to predict the combination treatment of oestrogen deprivation and palbociclib. We illustrate the model's potential to explore protocols that limit proliferation and hold off resistance by not depending on any one therapy.Within the framework of a biomimetic top-down approach, our study started with the technical question of the development of a hinge-free and compliant actuator inspired by plant movements. One meaningful biological concept generator was the opening and closing movements of the leaf halves of grasses.