https://www.selleckchem.com/pr....oducts/Cyclopamine.h
Both signs (evidenced by TBUT and Schirmer's test) and symptoms (measured by corneal sensitivity) improved significantly. The best formulation was the solution formulation; a cyclodextrin-based formulation was also successful but the emulsion formulation was not. PS and its metabolites were essentially restricted to the anterior chamber of the eye. Sulindac and phospho-ibuprofen amide had no efficacy on DED. Conclusions PS is efficacious against DED. Its effect, encompassing signs, and symptoms, are dose, formulation, and structure