https://www.selleckchem.com/pr....oducts/i-bet151-gsk1
Two cell lines, A549 (human-derived nonsmall-cell lung cancer) and 1c1c7 (mouse hepatoma), were photosensitized with m-THPC and irradiated under LD90 conditions. After 4 h, a pattern of cytoplasmic vacuoles had formed consistent with the initiation of paraptosis. After irradiation, there was no detectable loss of the mitochondrial membrane potential indicating no significant photodamage to mitochondria. We did, however, observe localization of m-THPC in the endoplasmic reticulum (ER), as indicated by fluorescence microscopy
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