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ADHD Treatment For Adults Stimulants like methylphenidate and amphetamine increase the levels of certain brain chemicals. Nonstimulants, like antidepressants and atomoxetine, work slower than stimulants, but may also be helpful. The comorbidity of conditions can alter the effectiveness to ADHD medication. Doctors should treat the most severe symptoms of any co-occurring disorder first, and then monitor whether the ADHD symptoms improve. Medication Adults wit