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The purpose of this systematic review was to provide the answer to the question Can sodium hypochlorite and chlorhexidine influence postoperative pain after the endodontic treatment in necrotic teeth? The PROSPERO registration number is CRD42018096433 and was conducted following the PRISMA statements. The MeSH and free terms were used to search for articles published in the electronic databases (PubMed, Web of Science, Scopus, Cochrane Library, and Virtual Health Library), in the gray literature, and by a manual search. The reviewers se