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05), but not with age, sex, serum carcinoembryonic antigen, serum CA199, or PGI/PGII (P 0.05). The positive rate of PRRX1 protein expression was positively correlated with the protein expression of Smad2 and vimentin, but negatively correlated with E-cadherin protein. PRRX1, Smad2, and vimentin proteins are associated with Borrmann type, lymph node positives, histologic grade, depth of tumor invasion, and serum PGI levels, all of which contribute to a poor prognosis for patients with gastric cancer. The positive rate of PRRX1 prot