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Conclusion sOKGM-PS-miR-31i/Cur microspheres work rectal distribution system with connected benefits of mucoadhesive and mucus-penetrating properties, representing a potent and viable healing approach for CRC. © The author(s).Background infection and steatosis would be the primary pathological features of alcoholic liver disease (ALD), for which, infection is just one of the vital drivers when it comes to initiation and improvement alcoholic steatosis. NIK, an inflammatory pathway component activ