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Health Issues That Affect German Shepherd Life Expectancy German Shepherds peak between the ages of 2 and 6. They're at their strongest in terms of physical fitness and mental toughness. They are more at risk of developing diseases of the musculoskeletal system, cancer, and other health conditions which could affect their lives. Working line German Shepherds typically have more active lives than their show line counterparts. They require a nutrient-rich diet to