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From the limited evidence of the study, it can be concluded that soft tissue changes following AMO setback in southern Dravidian population and the Caucasian population are almost similar. This systematic review and meta-analysis aimed to evaluate if bioceramic sealers had superior sealing properties to epoxy resin-based sealers. A systematic search was performed in the following databases MEDLINE Ovid (from 1946 onwards), Scopus, Google Scholar, EBSCO, and a hand search of references of included articles was also done. In vitro and ex