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Using the new platform, it is found that localized cell proliferation and coordinated cell migration result in elongation morphogenesis of the P19C5 aggregates. Further, it is found that polarization and elongation of mESC aggregates are dependent on directed cell migration. © 2020 The Authors. Published by WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.OBJECTIVES Although sleep disturbances are prevalent among patients with dementia with Lewy bodies (DL, their neural substrates remain unclear. We aimed to clarify the neural substrates o