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Adult ADHD and Comorbid Disorders Many people with ADHD have comorbid disorders like major depression (Kessler and co., 2006). Many depressed patients aren't able to take medications and may benefit from therapy. The most effective medications to treat the most fundamental symptoms of ADHD appear to increase and balance levels of specific neurotransmitters in the brain. The most frequently prescribed stimulants include methylphenidate, amphetamine and other similar medications. Medicines Adults are able to take many different medications t