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54 for cCR and 0.93 for pCR. At the external validation, ΔL showed an accuracy of 81% for cCR and 79% for pCR, while Δglnu reported 63% for cCR and 40% for pCR. The accuracy of ΔL in predicting cCR and pCR is significantly higher than those obtained considering Δglnu, but inferior if compared with other image-based biomarker, such as the early-regression index. Studies with larger cohorts of patients are recommended to further investigate the role of delta radiomic features in MRgRT. The accuracy of ΔLleast in predicting cCR and pCR is si
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