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Techniques Bibliographic databases were methodically searched for relevant articles published by November 2020. The primary endpoints were suffered viral reaction after 12 weeks (SVR12), unpleasant events (AEs; any quality) and extreme damaging events (SAEs). Publication prejudice assessment was done using funnel plots as well as the Egger's test. Outcomes Fourteen scientific studies composed of an overall total of 1,294 topics were most notable study and the pooled estimate of SVR12,