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Treatment For ADHD Psychosocial therapy is the main treatment for add. The drugs include stimulants such as methylphenidate, amphetamine, and Atomoxetine. They may also be non-stimulants, such as clonidine and Guanfacine. Patients who have active issues with substance abuse should not take stimulant medications. However, those in stable remission might look into them. Combination therapy with antidepressants (particularly SSRIs) is also an option. Stimulants Stimulants boost the levels of dopamine and norepinephrine that ar