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Low basal endogenous concentrations (80%) of plasma LTE4 level was observed, providing pharmacological evidence that endogenous 5-LO pathway activity could be assessed.Background India is now regarded unfortunately as the country with one of the highest incidence of oral cancer in the world. Considering poor survival in cases with late diagnosis, early detection can reduce morbidity and mortality of cancer patients and impede malignant transformation in cases of oral potentially malignant disorders (OPMD). Most of the diagnostic aids a