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Nonlinear correlations between metamorphosis-associated bioamplification and the octanol-water partition coefficients of SCCPs and MCCPs were observed for insects, whereas negative linear correlations were observed for amphibians, which suggested species-specific alterations to the chemicals during metamorphosis.There is a critical need to find safe therapeutics to treat an increasingly obese population and diseases associated with an imbalance in energy homeostasis. The melanocortin-3 receptor (MC3R) and melanocortin-4 receptor (MC4R)
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